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Season 1 Episode 6. All Episodes 6. Susan Cushing asks Holmes' help in solving the disappearance of her sister Mary Browner, but it doesn't seem Holmes' type of case until he is told of a Christmas present's grisly contents. Director: Sarah Hellings.

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You must be a registered user to use the IMDb rating plugin. Photos Add Image. Edit Cast Episode complete credited cast: Jeremy Brett Sherlock Holmes Edward Hardwicke Doctor Watson Rosalie Williams Susan Cushing Deborah Findlay Sarah Cushing Lucy Whybrow Mary Browner Tom Chadbon Inspector Hawkins Thierry Harcourt Marcel Jacottet Richard Dixon Mr Bradbrook Renny Krupinski Reading the expression on his face, Sherlock waves dismissively.

So I love the Sherlock Holmes canon. Love it. They are what started it all. I know, its not really fair. Its the snob in me coming out. I always thought the stories would be kind of dry but they were and I love original Holmes and Watson and their bromance and just everything. What object is served by this circle of misery and violence and fear? It must tend to some end, or else our universe is ruled by chance, which in unthinkable. What what end? There is the great perennial problem to which human reason is as far from an answer as ever.

Click the read more to read about some behind-the-scenes facts and easter eggs from our second full-length episode! Baker Street was like an oven, and the glare of the sunlight upon the yellow brickwork of the house across the road was painful to the eye. You read it at some point during the week and then you blog about it on Friday.

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Currently reading the Adventure of the Cardboard Box. Log in Sign up. Sherlock Holmes museology museum problems the adventure of the cardboard box. In , Peacock et al demonstrated this to be a mathematical inevitability 7. Later validated by Bassler et al in a meta-analysis examining 91 trials stopped prematurely for benefit 8.

Bassler et al revealed that the degree of embellishment was directly related to the size of the sample population at cessation and independent of the quality of the trial or the presence of a predetermined methodology for early stoppage. Although the exact patient population that stands to benefit from endovascular therapy is unclear, it is certainly a small fraction of the overall patients who present to the Emergency Department with acute ischemic stroke.

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SONIA catalogued patients only Only 4. This accounts for a small minority of the stroke patients presenting to the Emergency Department with symptoms consistent with acute ischemic stroke. That comes out to 0. Even the most skeptical will find difficulty denying there is a definite treatment effect observed in the recent trials examining endovascular therapy in acute ischemic stroke. The magnitude of this effect has yet to be defined.

Its borders are obscured by the murkiness of small sample sizes, extreme selection bias and prematurely stopped trials. There are also clear harms associated with this invasive procedure. This is simply not a yes or no question. The resources required to build an infrastructure capable of supporting endovascular therapy on a national level are daunting. Though we have reached a certain degree of clarity that endovascular therapy for acute ischemic stroke provides benefit, how well and in whom remains murky.

The overeager truncation of important trials has left us adrift in a sea of fog. Unsure if the shoreline we paddle towards is a warm welcoming beachfront or a rocky coast prepared to demolish our vessel upon arrival. Thank you for your well researched review of this topic Rory. However, I do not believe that it is ethically justifiable to deny a patient this therapy in order to satisfy this point.

I believe that given the weight of the evidence to date, we must accept that endovascular treatment is effective under the conditions studied in this trial, and we must ensure that it can be offered to eligible patients. Thank you Stephen for your thoughtful reply. Far smarter people have been debating these points and have yet to come up with a satisfactory answer. Yes you are correct from an individual patient prospective an NNT of 3 vs an NNT of 7 does not make much of a difference but from a societal standpoint it makes a huge difference.

Are these benefits worth the resources that will be required to establish the infrastructure needed to support endovascular therapy?

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What percent of stroke patients are eligible for endovascular therapy? What percentage of these patients actual benefit from endovascular therapy? Either way this cohort of patients is diminishingly small.

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